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| Product Name | InVivoPro Anti-Mouse HMGB1 in vivo antibody |
| Size | 1mg |
| Subtype | Mouse IgG1 |
| Clone | DPH1.1.1 |
| Target | HMGB1/HMGB1s |
| Alias | High mobility group protein B1; High mobility group protein 1; HMG-1 |
| Isotype Control | Mouse IgG1 |
| Diluent | PBS, pH 7.2, contains no stabilizers or preservatives |
| Reactivity Species | human, mouse, rat |
| Host | Mouse |
| Recommended Dosage | 220 ug/mouse |
| Background | Human High-mobility group box 1 protein (HMGB1), also known as HMG-1 or amphoterin, belongs to the high mobility group box family of non-histone chromosomal proteins. This 30 kDa, 215-amino acid single-chain polypeptide contains three domains: two N-terminal 70-amino acid positively charged DNA-binding HMG boxes (A and B), and a negatively charged 30-amino acid C-terminal region (Asp/Glu-rich). Nuclear localization signals (NLS) reside at residues 27-43 and 178-184. Posttranslational acetylation of up to 17 lysine residues has been reported. HMGB1 is highly expressed in most cells. |
| Application Type | In vivo blocks recruitment of inflammatory cells to sites of necrosis and infection |
| Purification | protein A or G |
| Storage | 2-8 ℃ |
| Transportation | 2-8°C with blue ice |
| Validity Period | 6 months from the date of receipt if stored as recommended |
| Sterility | 0.2 μM filtered |
| Purity | >95% |
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