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IFNβ is a type I interferon cytokine that binds its high-affinity (IFNAR2) and low-affinity (IFNAR1) subunits of the heterodimeric type I IFN receptor (IFNAR), activating canonical JAK-STAT and MAPK signaling to drive transcriptional regulation of IFN-stimulated genes (ISGs). IFNβ plays a significant role in innate immunity to infections, tumorigenesis, and inflammation. In most cell types, IFNβ is induced after microbial detection through pattern-recognition receptors (PRRs) and the subsequent activation/nuclear translocation of IRF-family transcription factor-1 (IRF-1) and IRF-3. IFNβ elicits antimicrobial activities and regulates the LPS-inducible TNF production. IFNβ directly mobilizes systemic immune responses through enhanced antigen presentation, NK cell activation, and T-cell effector function.The HDβ-4A7 monoclonal antibody recognizes an epitope on mouse IFNß and binds specifically to mouse IFNß and does not bind mouse IFNγ or several different IFNα isoforms (α1,4,5 or 13).
| Catalog | IV0140 |
| Product Name | InVivoPro Anti-Mouse IFNß in vivo antibody, Clone HDß-4A7 |
| Size | 1mg/5mg/25mg/50mg/100mg |
| Isotype | Mouse IgG2a κ |
| Clone | HDß-4A7 |
| Target | IFNß |
| Other Names | IFN-b, IFN-beta, Type-1 interferon |
| Isotype Control Catalog Code | IV0137 or Mouse IgG2a Isotype Control |
| Dilution Buffer | PBS, pH 7.2, contains no stabilizers or preservatives |
| Reactivity | Mouse |
| Host Species | Mouse |
| How much antibody to use in vivo | Each investigator should determine their own optimal working dilution for specific applications. |
| Background | IFNβ is a type I interferon cytokine that binds its high-affinity (IFNAR2) and low-affinity (IFNAR1) subunits of the heterodimeric type I IFN receptor (IFNAR), activating canonical JAK-STAT and MAPK signaling to drive transcriptional regulation of IFN-stimulated genes (ISGs). IFNβ plays a significant role in innate immunity to infections, tumorigenesis, and inflammation. In most cell types, IFNβ is induced after microbial detection through pattern-recognition receptors (PRRs) and the subsequent activation/nuclear translocation of IRF-family transcription factor-1 (IRF-1) and IRF-3. IFNβ elicits antimicrobial activities and regulates the LPS-inducible TNF production. IFNβ directly mobilizes systemic immune responses through enhanced antigen presentation, NK cell activation, and T-cell effector function.The HDβ-4A7 monoclonal antibody recognizes an epitope on mouse IFNß and binds specifically to mouse IFNß and does not bind mouse IFNγ or several different IFNα isoforms (α1,4,5 or 13). |
| Applications | in vivo neutralization of IFNβ |
| Purification | protein A or G |
| Storage | This antibody is stable for at least 2 months when stored at 2-8°C. For long term storage, aliquot in working volumes without diluting and store at -20°C or -80°C. Avoid repeated freeze thaw cycles. |
| Shipping | 2-8°C with blue ice |
| Concentration | Lot specific |
| Shelf Life | 12 months from the date of receipt if stored as recommended |
| Formulation | PBS Buffer, PH 7.2, with no carrier protein, or preservatives. |
| Sterility | 0.2 μM filtered |
| Endotoxin | ≤ 1.0 EU/mg, by the LAL method |
| Purity | 99% |
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