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This non-therapeutic Ustekinumab biosimilar (same variable regions, ideal for research) binds human p40 (IL-12β, 40 kDa subunit of IL-12/IL-23). IL-12 (from activated monocytes/macrophages/dendritic cells) aids T lymphocyte differentiation, IFNγ production, NK cell cytotoxicity; IL-23 from dendritic/epithelial cells. C17.8 neutralizes IL-12/IL-23; Ustekinumab treats Crohn’s disease, plaque psoriasis, psoriatic arthritis.
| Product Name | BioSIM anti-Human IL-12 Antibody (Ustekinumab Biosimilar), Research Grade |
| Size | 1mg/5mg |
| Isotype | IgG1-kappa |
| Target | IL-12 |
| Other Names | CNTO1275, TT-20, BFI-751, AVT04, CAS: 815610-63-0 |
| CAS | 815610-63-0 |
| Reactivity | Human |
| Host Species | Human |
| Background | This non-therapeutic Ustekinumab biosimilar (same variable regions, ideal for research) binds human p40 (IL-12β, 40 kDa subunit of IL-12/IL-23). IL-12 (from activated monocytes/macrophages/dendritic cells) aids T lymphocyte differentiation, IFNγ production, NK cell cytotoxicity; IL-23 from dendritic/epithelial cells. C17.8 neutralizes IL-12/IL-23; Ustekinumab treats Crohn’s disease, plaque psoriasis, psoriatic arthritis. |
| Applications | ELISA, FACS, Functional assay, Research in vivo |
| Purification | Protein A/G |
| Storage | To ensure appropriate storage, Please avoid repeated freeze thaw cycles. Keep the product at 4°C for short-term needs (1–2 weeks); Store at -20°C for up to 12 months. For long-term storage, store at -80°C. |
| Shipping | 2-8°C with blue ice |
| Concentration | Lot specific, generally ≥ 5.0 mg/ml |
| Shelf Life | 12 months from the date of receipt if stored as recommended |
| Formulation | PBS, pH 7.4, contains no stabilizers or preservatives |
| Sterility | 0.2 μM filtered |
| Endotoxin | ≤ 1.0 EU/mg |
| Purity | 99% |
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