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BiosimilarsInvestigate biological therapeutic mechanisms with cost-effective, research-grade biosimilar antibodies.
This non-therapeutic biosimilar has the same variable regions as Sarilumab, ideal for research. Sarilumab (humanized IgG1 mAb) targets IL-6R (aka CD126/IL6RA/gp80/IL6Q/HIES5, 80 kDa type I cytokine regulating cell growth/immunity, expressed in T/B cells etc.). It needs gp130 for signaling, blocks IL-6R in vitro/in vivo, binds IL-6R 15x more than tocilizumab, and works on human/cynomolgus monkey but not mouse IL-6R.
| Product Name | BioSIM anti-Human IL-6RA/CD126 Antibody (Sarilumab Biosimilar), Research Grade |
| Size | 1mg/5mg |
| Isotype | IgG1-kappa |
| Target | IL-6RA/CD126 |
| Other Names | REGN88, SAR153191, CAS: 1189541-98-7 |
| CAS | 1189541-98-7 |
| Reactivity | Human |
| Host Species | Human |
| Background | This non-therapeutic biosimilar has the same variable regions as Sarilumab, ideal for research. Sarilumab (humanized IgG1 mAb) targets IL-6R (aka CD126/IL6RA/gp80/IL6Q/HIES5, 80 kDa type I cytokine regulating cell growth/immunity, expressed in T/B cells etc.). It needs gp130 for signaling, blocks IL-6R in vitro/in vivo, binds IL-6R 15x more than tocilizumab, and works on human/cynomolgus monkey but not mouse IL-6R. |
| Applications | ELISA, FACS, Functional assay, Research in vivo |
| Purification | Protein A/G |
| Storage | To ensure appropriate storage, Please avoid repeated freeze thaw cycles. Keep the product at 4°C for short-term needs (1–2 weeks); Store at -20°C for up to 12 months. For long-term storage, store at -80°C. |
| Shipping | 2-8°C with blue ice |
| Concentration | Lot specific |
| Shelf Life | 12 months from the date of receipt if stored as recommended |
| Formulation | PBS, pH 7.4, contains no stabilizers or preservatives |
| Sterility | 0.2 μM filtered |
| Endotoxin | ≤ 1.0 EU/mg |
| Purity | 99% |
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