Discover our extensive collection of research-grade antibodies,
rigorously validated for in vivo applications.
Precisely identify antibody-specific signals using matched isotype controls optimised for in vivo experimentation.
BiosimilarsInvestigate biological therapeutic mechanisms with cost-effective, research-grade biosimilar antibodies.
This non-therapeutic biosimilar antibody shares variable regions with therapeutic Ipilimumab, ideal for research. It binds human CTLA-4 (CD152) — a 33 kDa Ctla4-encoded receptor (CD28 family, on activated T/B cells) that, like CD28, binds B7-1/B7-2. CTLA-4 negatively regulates cell-mediated immunity, aids immune tolerance, and is a cancer immune checkpoint target. Ipilimumab blocks its inhibitory signal, enabling cytotoxic T cells to kill cancer cells.
| Product Name | BioSIM anti-Human CTLA-4/CD152 Antibody (Ipilimumab Biosimilar), Research Grade |
| Size | 1mg/5mg |
| Isotype | IgG1-kappa |
| Target | CTLA-4/CD152 |
| Other Names | BMS-734016, MDX-010, MDX-CTLA-4, CAS: 477202-00-9 |
| CAS | 477202-00-9 |
| Reactivity | Human |
| Host Species | Human |
| Background | This non-therapeutic biosimilar antibody shares variable regions with therapeutic Ipilimumab, ideal for research. It binds human CTLA-4 (CD152) — a 33 kDa Ctla4-encoded receptor (CD28 family, on activated T/B cells) that, like CD28, binds B7-1/B7-2. CTLA-4 negatively regulates cell-mediated immunity, aids immune tolerance, and is a cancer immune checkpoint target. Ipilimumab blocks its inhibitory signal, enabling cytotoxic T cells to kill cancer cells. |
| Applications | ELISA, FACS, Functional assay, Research in vivo |
| Purification | Protein A/G |
| Storage | To ensure appropriate storage, Please avoid repeated freeze thaw cycles. Keep the product at 4°C for short-term needs (1–2 weeks); Store at -20°C for up to 12 months. For long-term storage, store at -80°C. |
| Shipping | 2-8°C with blue ice |
| Concentration | Lot specific, generally ≥ 5.0 mg/ml |
| Shelf Life | 12 months from the date of receipt if stored as recommended |
| Formulation | PBS, pH 7.4, contains no stabilizers or preservatives |
| Sterility | 0.2 μM filtered |
| Endotoxin | ≤ 1.0 EU/mg |
| Purity | 99% |
© 2021-2025 InvivoCrown Limited. All rights reserved.