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This non-therapeutic biosimilar antibody shares variable regions with therapeutic eldelumab (a humanized IgG1, κ mAb binding pro-inflammatory CXCL10/IP-10), fitting research use. Eldelumab’s Fc is engineered (K214R substitution) to reduce ADCC/CDC. CXCL10 acts via CXCR3; eldelumab neutralizes CXCL10 in vitro (e.g., with CXCL10-stimulated PBMCs).
| Product Name | BioSIM anti-Human CXCL10/IP-10 Antibody (Eldelumab Biosimilar), Research Grade |
| Size | 1mg/5mg |
| Isotype | IgG1-kappa |
| Target | CXCL10/IP-10 |
| Other Names | BMS-936557, MDX-1100, CAS: 946414-98-8 |
| CAS | 946414-98-8 |
| Reactivity | Human |
| Host Species | Human |
| Background | This non-therapeutic biosimilar antibody shares variable regions with therapeutic eldelumab (a humanized IgG1, κ mAb binding pro-inflammatory CXCL10/IP-10), fitting research use. Eldelumab’s Fc is engineered (K214R substitution) to reduce ADCC/CDC. CXCL10 acts via CXCR3; eldelumab neutralizes CXCL10 in vitro (e.g., with CXCL10-stimulated PBMCs). |
| Applications | ELISA, FACS, Functional assay, Research in vivo |
| Purification | Protein A/G |
| Storage | To ensure appropriate storage, Please avoid repeated freeze thaw cycles. Keep the product at 4°C for short-term needs (1–2 weeks); Store at -20°C for up to 12 months. For long-term storage, store at -80°C. |
| Shipping | 2-8°C with blue ice |
| Concentration | Lot specific |
| Shelf Life | 12 months from the date of receipt if stored as recommended |
| Formulation | PBS, pH 7.4, contains no stabilizers or preservatives |
| Sterility | 0.2 μM filtered |
| Endotoxin | ≤ 1.0 EU/mg |
| Purity | 99% |
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