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BiosimilarsInvestigate biological therapeutic mechanisms with cost-effective, research-grade biosimilar antibodies.
This non-therapeutic biosimilar antibody shares the same variable regions as therapeutic Teprotumumab, ideal for research. Teprotumumab (a fully human IgG1 mAb) targets IGF-1R (upregulated in TED, forms complexes with TSHR in orbital fibroblasts to trigger orbital inflammation/remodeling). IGF-1 activates IGF-1R (regulates cell growth/metabolism, aids muscle regeneration, links to cancer). Teprotumumab binds IGF-1R’s α-subunit, blocking PI3K/AKT and MAPK/ERK pathways to reduce inflammation and hyaluronan production.
| Product Name | BioSIM anti-Human CD221/IGF1R Antibody (Teprotumumab Biosimilar), Research Grade |
| Size | 1mg/5mg |
| Isotype | IgG1 |
| Target | CD221/IGF1R |
| Other Names | RO4858696-000, CAS: 1036734-93-6 |
| CAS | 1036734-93-6 |
| Reactivity | Human |
| Host Species | Human |
| Background | This non-therapeutic biosimilar antibody shares the same variable regions as therapeutic Teprotumumab, ideal for research. Teprotumumab (a fully human IgG1 mAb) targets IGF-1R (upregulated in TED, forms complexes with TSHR in orbital fibroblasts to trigger orbital inflammation/remodeling). IGF-1 activates IGF-1R (regulates cell growth/metabolism, aids muscle regeneration, links to cancer). Teprotumumab binds IGF-1R’s α-subunit, blocking PI3K/AKT and MAPK/ERK pathways to reduce inflammation and hyaluronan production. |
| Applications | ELISA, FACS, Functional assay, Research in vivo |
| Purification | Protein A/G |
| Storage | To ensure appropriate storage, Please avoid repeated freeze thaw cycles. Keep the product at 4°C for short-term needs (1–2 weeks); Store at -20°C for up to 12 months. For long-term storage, store at -80°C. |
| Shipping | 2-8°C with blue ice |
| Concentration | Lot specific |
| Shelf Life | 12 months from the date of receipt if stored as recommended |
| Formulation | PBS, pH 7.4, contains no stabilizers or preservatives |
| Sterility | 0.2 μM filtered |
| Endotoxin | ≤ 1.0 EU/mg |
| Purity | 99% |
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