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This non-therapeutic biosimilar antibody shares variable regions with therapeutic Ponsegromab, ideal for research. It targets GDF15 (a TGF-β superfamily cytokine, key in energy homeostasis/appetite/stress, upregulated in stress/injury/inflammation/malignancy). Ponsegromab (human IgG1) binds circulating GDF15, blocking its GFRAL interaction, reversing cachexia-associated anorexia in preclinical models. Useful to study GDF15-GFRAL axis, model GDF15 therapeutic blockade, and explore appetite/weight regulation in diseases.
| Product Name | BioSIM anti-Human GDF15 Antibody (Ponsegromab Biosimilar), Research Grade |
| Size | 1mg/5mg |
| Isotype | / |
| Target | GDF15 |
| Other Names | PF-06946860, CAS: 2368950-15-4 |
| CAS | 2368950-15-4 |
| Reactivity | Human |
| Host Species | Humanized |
| Background | This non-therapeutic biosimilar antibody shares variable regions with therapeutic Ponsegromab, ideal for research. It targets GDF15 (a TGF-β superfamily cytokine, key in energy homeostasis/appetite/stress, upregulated in stress/injury/inflammation/malignancy). Ponsegromab (human IgG1) binds circulating GDF15, blocking its GFRAL interaction, reversing cachexia-associated anorexia in preclinical models. Useful to study GDF15-GFRAL axis, model GDF15 therapeutic blockade, and explore appetite/weight regulation in diseases. |
| Applications | ELISA, FACS, Functional assay, Research in vivo |
| Purification | Protein A/G |
| Storage | To ensure appropriate storage, Please avoid repeated freeze thaw cycles. Keep the product at 4°C for short-term needs (1–2 weeks); Store at -20°C for up to 12 months. For long-term storage, store at -80°C. |
| Shipping | 2-8°C with blue ice |
| Concentration | Lot specific, generally ≥ 5.0 mg/ml |
| Shelf Life | 12 months from the date of receipt if stored as recommended |
| Formulation | PBS, pH 7.4, contains no stabilizers or preservatives |
| Sterility | 0.2 μM filtered |
| Endotoxin | ≤ 1.0 EU/mg |
| Purity | 99% |
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