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This biosimilar has the same variable regions as therapeutic antibody Burosumab, ideal for research. Burosumab (fully human IgG1 mAb) targets FGF-23, blocking its FGFR1–α-Klotho binding to restore phosphate homeostasis. Clinically approved for adult/child XLH and TIO, it boosts serum phosphate, improves bone health, with sustained efficacy/safety. The biosimilar suits studying phosphate/vitamin D metabolism, FGF signaling, bone biology, and FGF-23 blockade.
| Product Name | BioSIM anti-Human FGF23 Antibody (Burosumab Biosimilar), Research Grade |
| Size | 1mg/5mg |
| Isotype | / |
| Target | FGF23 |
| Other Names | KRN-23, UX-023, CAS: 1610833-03-8 |
| CAS | 1610833-03-8 |
| Reactivity | Human |
| Host Species | Human |
| Background | This biosimilar has the same variable regions as therapeutic antibody Burosumab, ideal for research. Burosumab (fully human IgG1 mAb) targets FGF-23, blocking its FGFR1–α-Klotho binding to restore phosphate homeostasis. Clinically approved for adult/child XLH and TIO, it boosts serum phosphate, improves bone health, with sustained efficacy/safety. The biosimilar suits studying phosphate/vitamin D metabolism, FGF signaling, bone biology, and FGF-23 blockade. |
| Applications | ELISA, FACS, Functional assay, Research in vivo |
| Purification | Protein A/G |
| Storage | To ensure appropriate storage, Please avoid repeated freeze thaw cycles. Keep the product at 4°C for short-term needs (1–2 weeks); Store at -20°C for up to 12 months. For long-term storage, store at -80°C. |
| Shipping | 2-8°C with blue ice |
| Concentration | Lot specific, generally ≥ 5.0 mg/ml |
| Shelf Life | 12 months from the date of receipt if stored as recommended |
| Formulation | PBS, pH 7.4, contains no stabilizers or preservatives |
| Sterility | 0.2 μM filtered |
| Endotoxin | ≤ 1.0 EU/mg |
| Purity | 99% |
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