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This non-therapeutic biosimilar antibody, using Tezepelumab’s variable regions, suits research and binds human TSLP (a cytokine related to IL-7). TSLP is expressed in epithelial/stromal/mast/dendritic cells, acts via IL-7Rα/TSLPR, is NF-κB-regulated, drives Th2 differentiation (linked to atopic dermatitis/asthma), and affects B cells/Tregs/basophils. Tezepelumab treats moderate-severe asthma by blocking TSLP-receptor binding.
| Product Name | BioSIM anti-Human TSLP Antibody (Tezepelumab Biosimilar), Research Grade |
| Size | 1mg/5mg |
| Isotype | / |
| Target | TSLP |
| Other Names | AMG157, AMG-157, MEDI-9929, MEDI9929, anti-TSLP-Receptor(TSLP-R, Crl2), CAS: 1572943-04-4 |
| CAS | 1572943-04-4 |
| Reactivity | Human |
| Host Species | Human |
| Background | This non-therapeutic biosimilar antibody, using Tezepelumab’s variable regions, suits research and binds human TSLP (a cytokine related to IL-7). TSLP is expressed in epithelial/stromal/mast/dendritic cells, acts via IL-7Rα/TSLPR, is NF-κB-regulated, drives Th2 differentiation (linked to atopic dermatitis/asthma), and affects B cells/Tregs/basophils. Tezepelumab treats moderate-severe asthma by blocking TSLP-receptor binding. |
| Applications | ELISA, FACS, Functional assay, Research in vivo |
| Purification | Protein A/G |
| Storage | To ensure appropriate storage, Please avoid repeated freeze thaw cycles. Keep the product at 4°C for short-term needs (1–2 weeks); Store at -20°C for up to 12 months. For long-term storage, store at -80°C. |
| Shipping | 2-8°C with blue ice |
| Concentration | Lot specific, generally ≥ 5.0 mg/ml |
| Shelf Life | 12 months from the date of receipt if stored as recommended |
| Formulation | PBS, pH 7.4, contains no stabilizers or preservatives |
| Sterility | 0.2 μM filtered |
| Endotoxin | ≤ 1.0 EU/mg |
| Purity | 99% |
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