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Precisely identify antibody-specific signals using matched isotype controls optimised for in vivo experimentation.
BiosimilarsInvestigate biological therapeutic mechanisms with cost-effective, research-grade biosimilar antibodies.
This non-therapeutic biosimilar shares the same variable regions as therapeutic Romosozumab, ideal for research. Romosozumab is a humanized IgG2κ monoclonal antibody targeting osteocyte-secreted sclerostin (SOST). SOST negatively regulates bone formation by binding LRP4/5/6 and inhibiting Wnt/β-catenin signaling (key for osteoblasts). The biosimilar neutralizes SOST to promote bone formation and suppress resorption, supporting studies on osteoanabolic mechanisms, Wnt signaling, and SOST function in bone biology.
| Product Name | BioSIM anti-Human SOST/Sclerostin Antibody (Romosozumab Biosimilar), Research Grade |
| Size | 1mg/5mg |
| Isotype | / |
| Target | SOST/Sclerostin |
| Other Names | 785A070802, AMG785, CDP-7851, romosozumab-aqqg, sclerostinAb, CAS: 909395-70-6 |
| CAS | 909395-70-6 |
| Reactivity | Human |
| Host Species | Humanized |
| Background | This non-therapeutic biosimilar shares the same variable regions as therapeutic Romosozumab, ideal for research. Romosozumab is a humanized IgG2κ monoclonal antibody targeting osteocyte-secreted sclerostin (SOST). SOST negatively regulates bone formation by binding LRP4/5/6 and inhibiting Wnt/β-catenin signaling (key for osteoblasts). The biosimilar neutralizes SOST to promote bone formation and suppress resorption, supporting studies on osteoanabolic mechanisms, Wnt signaling, and SOST function in bone biology. |
| Applications | ELISA, FACS, Functional assay, Research in vivo |
| Purification | Protein A/G |
| Storage | To ensure appropriate storage, Please avoid repeated freeze thaw cycles. Keep the product at 4°C for short-term needs (1–2 weeks); Store at -20°C for up to 12 months. For long-term storage, store at -80°C. |
| Shipping | 2-8°C with blue ice |
| Concentration | Lot specific, generally ≥ 5.0 mg/ml |
| Shelf Life | 12 months from the date of receipt if stored as recommended |
| Formulation | PBS, pH 7.4, contains no stabilizers or preservatives |
| Sterility | 0.2 μM filtered |
| Endotoxin | ≤ 1.0 EU/mg |
| Purity | 99% |
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