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This non-therapeutic biosimilar shares the same variable regions as therapeutic Nemolizumab (a humanized IgG2 mAb targeting IL-31RA), ideal for research. IL-31RA mediates IL-31’s effects (pruritus, inflammation, etc.). Nemolizumab blocks IL-31 signaling, interrupts itch-scratch cycles in AD/PN, and relieves pruritus clinically. The biosimilar suits studying IL-31 signaling, neuroimmune interactions, and anti-pruritic therapeutics development.
| Product Name | BioSIM anti-Human IL-31Ra Antibody (Nemolizumab Biosimilar), Research Grade |
| Size | 1mg/5mg |
| Isotype | / |
| Target | IL-31Ra |
| Other Names | CIM331, CAS: 1476039-58-3, Nemolizumab |
| CAS | 1476039-58-3 |
| Reactivity | Human |
| Host Species | Humanized |
| Background | This non-therapeutic biosimilar shares the same variable regions as therapeutic Nemolizumab (a humanized IgG2 mAb targeting IL-31RA), ideal for research. IL-31RA mediates IL-31’s effects (pruritus, inflammation, etc.). Nemolizumab blocks IL-31 signaling, interrupts itch-scratch cycles in AD/PN, and relieves pruritus clinically. The biosimilar suits studying IL-31 signaling, neuroimmune interactions, and anti-pruritic therapeutics development. |
| Applications | ELISA, FACS, Functional assay, Research in vivo |
| Purification | Protein A/G |
| Storage | To ensure appropriate storage, Please avoid repeated freeze thaw cycles. Keep the product at 4°C for short-term needs (1–2 weeks); Store at -20°C for up to 12 months. For long-term storage, store at -80°C. |
| Shipping | 2-8°C with blue ice |
| Concentration | Lot specific, generally ≥ 5.0 mg/ml |
| Shelf Life | 12 months from the date of receipt if stored as recommended |
| Formulation | PBS, pH 7.4, contains no stabilizers or preservatives |
| Sterility | 0.2 μM filtered |
| Endotoxin | ≤ 1.0 EU/mg |
| Purity | 99% |
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