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BiosimilarsInvestigate biological therapeutic mechanisms with cost-effective, research-grade biosimilar antibodies.
This non-therapeutic Cemiplimab biosimilar (same variable regions as the therapeutic version, ideal for research) binds human PD-1 (CD279), a Pdcd1-encoded, 50-55 kDa CD28 family receptor on immune cells (e.g., T/B lymphocytes) with an ITIM motif. It blocks PD-1’s binding to ligands PD-L1/PD-L2; PD-L1 overexpression in tumors (e.g., breast adenocarcinoma) reduces CD8 T-cell lysis. Anti-PD-1 therapies treat cancer, and this biosimilar supports related research.
| Product Name | BioSIM anti-Human PD-1/CD279 Antibody (Cemiplimab Biosimilar), Research Grade |
| Size | 1mg/5mg |
| Isotype | / |
| Target | PD-1/CD279 |
| Other Names | REGN-2810, SAR-439684, cemiplimab-rwlc, CAS: 1801342-60-8 |
| CAS | 1801342-60-8 |
| Reactivity | Human |
| Host Species | Human |
| Background | This non-therapeutic Cemiplimab biosimilar (same variable regions as the therapeutic version, ideal for research) binds human PD-1 (CD279), a Pdcd1-encoded, 50-55 kDa CD28 family receptor on immune cells (e.g., T/B lymphocytes) with an ITIM motif. It blocks PD-1’s binding to ligands PD-L1/PD-L2; PD-L1 overexpression in tumors (e.g., breast adenocarcinoma) reduces CD8 T-cell lysis. Anti-PD-1 therapies treat cancer, and this biosimilar supports related research. |
| Applications | ELISA, FACS, Functional assay, Research in vivo |
| Purification | Protein A/G |
| Storage | To ensure appropriate storage, Please avoid repeated freeze thaw cycles. Keep the product at 4°C for short-term needs (1–2 weeks); Store at -20°C for up to 12 months. For long-term storage, store at -80°C. |
| Shipping | 2-8°C with blue ice |
| Concentration | Lot specific, generally ≥ 5.0 mg/ml |
| Shelf Life | 12 months from the date of receipt if stored as recommended |
| Formulation | PBS, pH 7.4, contains no stabilizers or preservatives |
| Sterility | 0.2 μM filtered |
| Endotoxin | ≤ 1.0 EU/mg |
| Purity | 99% |
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