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This non-therapeutic biosimilar antibody shares variable regions with therapeutic Onvatilimab, suiting research. Onvatilimab is a humanized IgG1 mAb targeting VISTA (VSIR/B7-H5) — an Ig superfamily type I transmembrane glycoprotein, immunoregulatory receptor, and negative immune checkpoint that suppresses T-cells, is expressed in myeloid/NK cells, and overexpressed in tumor-infiltrating lymphocytes. Preclinically, anti-VISTA mAbs reduce tumor MDSC infiltration and improve tumor-bearing mice survival.
| Product Name | BioSIM anti-Human B7-H5/VISTA Antibody (Onvatilimab Biosimilar), Research Grade |
| Size | 1mg/5mg |
| Isotype | / |
| Target | B7-H5/VISTA |
| Other Names | JNJ-61610588, CAS: 1969313-51-6 |
| CAS | 1969313-51-6 |
| Reactivity | Human |
| Host Species | Human |
| Background | This non-therapeutic biosimilar antibody shares variable regions with therapeutic Onvatilimab, suiting research. Onvatilimab is a humanized IgG1 mAb targeting VISTA (VSIR/B7-H5) — an Ig superfamily type I transmembrane glycoprotein, immunoregulatory receptor, and negative immune checkpoint that suppresses T-cells, is expressed in myeloid/NK cells, and overexpressed in tumor-infiltrating lymphocytes. Preclinically, anti-VISTA mAbs reduce tumor MDSC infiltration and improve tumor-bearing mice survival. |
| Applications | ELISA, FACS, Functional assay, Research in vivo |
| Purification | Protein A/G |
| Storage | To ensure appropriate storage, Please avoid repeated freeze thaw cycles. Keep the product at 4°C for short-term needs (1–2 weeks); Store at -20°C for up to 12 months. For long-term storage, store at -80°C. |
| Shipping | 2-8°C with blue ice |
| Concentration | Lot specific, generally ≥ 5.0 mg/ml |
| Shelf Life | 12 months from the date of receipt if stored as recommended |
| Formulation | PBS, pH 7.4, contains no stabilizers or preservatives |
| Sterility | 0.2 μM filtered |
| Endotoxin | ≤ 1.0 EU/mg |
| Purity | 99% |
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