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This non-therapeutic Eculizumab biosimilar, sharing the same variable regions as the therapeutic version, is ideal for research. It binds human terminal complement component C5 (a liver-synthesized precursor). During complement activation, C5 cleaves into C5α/C5β; C5α further splits, forming C5b that recruits C6-C9 to make MAC (destroying pathogens via lytic pores). Eculizumab inhibits C5 cleavage and treats PNH and aHUS.
| Product Name | BioSIM anti-Human complement C5 Antibody (Eculizumab Biosimilar), Research Grade |
| Size | 1mg/5mg |
| Isotype | IgG2-G4-kappa |
| Target | complement C5 |
| Other Names | 5G1.1, h5G1.1HuG2/G4, CAS: 219685-50-4 |
| CAS | 219685-50-4 |
| Reactivity | Human |
| Host Species | Humanized |
| Background | This non-therapeutic Eculizumab biosimilar, sharing the same variable regions as the therapeutic version, is ideal for research. It binds human terminal complement component C5 (a liver-synthesized precursor). During complement activation, C5 cleaves into C5α/C5β; C5α further splits, forming C5b that recruits C6-C9 to make MAC (destroying pathogens via lytic pores). Eculizumab inhibits C5 cleavage and treats PNH and aHUS. |
| Applications | ELISA, FACS, Functional assay, Research in vivo |
| Purification | Protein A/G |
| Storage | To ensure appropriate storage, Please avoid repeated freeze thaw cycles. Keep the product at 4°C for short-term needs (1–2 weeks); Store at -20°C for up to 12 months. For long-term storage, store at -80°C. |
| Shipping | 2-8°C with blue ice |
| Concentration | Lot specific, generally ≥ 5.0 mg/ml |
| Shelf Life | 12 months from the date of receipt if stored as recommended |
| Formulation | PBS, pH 7.4, contains no stabilizers or preservatives |
| Sterility | 0.2 μM filtered |
| Endotoxin | ≤ 1.0 EU/mg |
| Purity | 99% |
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