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BiosimilarsInvestigate biological therapeutic mechanisms with cost-effective, research-grade biosimilar antibodies.
This biosimilar antibody shares the same variable regions as therapeutic Amivantamab, ideal for research. Amivantamab, a fully human IgG1 bispecific monoclonal antibody, targets EGFR and MET, blocking ligand binding and promoting receptor internalization/degradation. Clinically approved for adults with EGFR exon 20 insertion-mutated NSCLC post-platinum chemotherapy progression, this biosimilar is only for research, suiting studies on receptor blockade, downmodulation and immune effector activation in EGFR/MET-driven tumor models.
| Product Name | BioSIM anti-Human EGFR x c-MET Bispecific Antibody (Amivantamab Biosimilar), Research Grade |
| Size | 1mg/5mg |
| Isotype | IgG1-kappa |
| Target | EGFR x c-MET |
| Other Names | Bispecific, JNJ-61186372, JNJ-6372, CNTO-4424, JNJ61186372, JNJ-611, CAS: 2171511-58-1 |
| CAS | 2171511-58-1 |
| Reactivity | Human |
| Host Species | Human |
| Background | This biosimilar antibody shares the same variable regions as therapeutic Amivantamab, ideal for research. Amivantamab, a fully human IgG1 bispecific monoclonal antibody, targets EGFR and MET, blocking ligand binding and promoting receptor internalization/degradation. Clinically approved for adults with EGFR exon 20 insertion-mutated NSCLC post-platinum chemotherapy progression, this biosimilar is only for research, suiting studies on receptor blockade, downmodulation and immune effector activation in EGFR/MET-driven tumor models. |
| Applications | ELISA, FACS, Functional assay, Research in vivo |
| Purification | Protein A/G |
| Storage | To ensure appropriate storage, Please avoid repeated freeze thaw cycles. Keep the product at 4°C for short-term needs (1–2 weeks); Store at -20°C for up to 12 months. For long-term storage, store at -80°C. |
| Shipping | 2-8°C with blue ice |
| Concentration | Lot specific, generally ≥ 5.0 mg/ml |
| Shelf Life | 12 months from the date of receipt if stored as recommended |
| Formulation | PBS, pH 7.4, contains no stabilizers or preservatives |
| Sterility | 0.2 μM filtered |
| Endotoxin | ≤ 1.0 EU/mg |
| Purity | 99% |
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