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This non-therapeutic biosimilar has Amatuximab’s variable regions, ideal for research. Amatuximab, a high-affinity chimeric mAb, binds mesothelin (MSLN)—a GPI-anchored glycoprotein (adult mesothelium-restricted, overexpressed in epithelial cancers, interacts with CA125, linked to tumorigenesis/metastasis, a cancer immunotherapy target). It elicits ADCC against MSLN+ cells in vitro and boosts efficacy in mouse xenografts with chemotherapy.
| Product Name | BioSIM anti-Human MSLN Antibody (Amatuximab Biosimilar), Research Grade |
| Size | 1mg/5mg |
| Isotype | IgG1-kappa |
| Target | MSLN |
| Other Names | MORAb-009, CAS: 931402-35-6 |
| CAS | 931402-35-6 |
| Reactivity | Human |
| Host Species | Chimeric |
| Background | This non-therapeutic biosimilar has Amatuximab’s variable regions, ideal for research. Amatuximab, a high-affinity chimeric mAb, binds mesothelin (MSLN)—a GPI-anchored glycoprotein (adult mesothelium-restricted, overexpressed in epithelial cancers, interacts with CA125, linked to tumorigenesis/metastasis, a cancer immunotherapy target). It elicits ADCC against MSLN+ cells in vitro and boosts efficacy in mouse xenografts with chemotherapy. |
| Applications | ELISA, FACS, Functional assay, Research in vivo |
| Purification | Protein A/G |
| Storage | To ensure appropriate storage, Please avoid repeated freeze thaw cycles. Keep the product at 4°C for short-term needs (1–2 weeks); Store at -20°C for up to 12 months. For long-term storage, store at -80°C. |
| Shipping | 2-8°C with blue ice |
| Concentration | Lot specific, generally ≥ 5.0 mg/ml |
| Shelf Life | 12 months from the date of receipt if stored as recommended |
| Formulation | PBS, pH 7.4, contains no stabilizers or preservatives |
| Sterility | 0.2 μM filtered |
| Endotoxin | ≤ 1.0 EU/mg |
| Purity | 99% |
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