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This non-therapeutic biosimilar antibody shares the same variable regions as therapeutic Glembatumumab (a fully human IgG2 mAb targeting GPNMB, a transmembrane glycoprotein overexpressed in cancers like TNBC, melanoma, linked to tumor progression). Therapeutically, Glembatumumab conjugates with MMAE to form ADC Glembatumumab vedotin, inducing cancer cell death. Unconjugated, this biosimilar is for research only, aiding GPNMB biology, tumor immunology, and targeted therapy development.
| Product Name | BioSIM anti-Human GPNMB Antibody (Glembatumumab Biosimilar), Research Grade |
| Size | 1mg/5mg |
| Isotype | IgG2-kappa |
| Target | GPNMB |
| Other Names | CDX-011(DOX), CR011, glembatumumabvedotin(ADC), CAS: 1020264-78-1 |
| CAS | 1020264-78-1 |
| Reactivity | Human |
| Host Species | Human |
| Background | This non-therapeutic biosimilar antibody shares the same variable regions as therapeutic Glembatumumab (a fully human IgG2 mAb targeting GPNMB, a transmembrane glycoprotein overexpressed in cancers like TNBC, melanoma, linked to tumor progression). Therapeutically, Glembatumumab conjugates with MMAE to form ADC Glembatumumab vedotin, inducing cancer cell death. Unconjugated, this biosimilar is for research only, aiding GPNMB biology, tumor immunology, and targeted therapy development. |
| Applications | ELISA, FACS, Functional assay, Research in vivo |
| Purification | Protein A/G |
| Storage | To ensure appropriate storage, Please avoid repeated freeze thaw cycles. Keep the product at 4°C for short-term needs (1–2 weeks); Store at -20°C for up to 12 months. For long-term storage, store at -80°C. |
| Shipping | 2-8°C with blue ice |
| Concentration | Lot specific, generally ≥ 5.0 mg/ml |
| Shelf Life | 12 months from the date of receipt if stored as recommended |
| Formulation | PBS, pH 7.4, contains no stabilizers or preservatives |
| Sterility | 0.2 μM filtered |
| Endotoxin | ≤ 1.0 EU/mg |
| Purity | 99% |
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