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BiosimilarsInvestigate biological therapeutic mechanisms with cost-effective, research-grade biosimilar antibodies.
This non-therapeutic biosimilar has the same variable regions as therapeutic loncastuximab (a humanized IgG1, κ mAb binding human B-cell marker CD19, ideal for ADCs/therapies). Its ADC, loncastuximab tesirine, exhibits strong in vitro cytotoxicity (linked to CD19 expression) and in vivo dose-dependent antitumor activity in CD19+ lymphoma models.
| Product Name | BioSIM anti-Human CD19 Antibody (Loncastuximab Biosimilar), Research Grade |
| Size | 1mg/5mg |
| Isotype | IgG1-kappa |
| Target | CD19 |
| Other Names | ADCT-402, RB4v1.2-SG-3249, CAS: 1875032-68-0 |
| CAS | 1875032-68-0 |
| Reactivity | Human |
| Host Species | Chimeric |
| Background | This non-therapeutic biosimilar has the same variable regions as therapeutic loncastuximab (a humanized IgG1, κ mAb binding human B-cell marker CD19, ideal for ADCs/therapies). Its ADC, loncastuximab tesirine, exhibits strong in vitro cytotoxicity (linked to CD19 expression) and in vivo dose-dependent antitumor activity in CD19+ lymphoma models. |
| Applications | ELISA, FACS, Functional assay, Research in vivo |
| Purification | Protein A/G |
| Storage | To ensure appropriate storage, Please avoid repeated freeze thaw cycles. Keep the product at 4°C for short-term needs (1–2 weeks); Store at -20°C for up to 12 months. For long-term storage, store at -80°C. |
| Shipping | 2-8°C with blue ice |
| Concentration | Lot specific, generally ≥ 5.0 mg/ml |
| Shelf Life | 12 months from the date of receipt if stored as recommended |
| Formulation | PBS, pH 7.4, contains no stabilizers or preservatives |
| Sterility | 0.2 μM filtered |
| Endotoxin | ≤ 1.0 EU/mg |
| Purity | 99% |
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