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This biosimilar antibody shares the same variable regions as therapeutic Pivekimab, ideal for research. Pivekimab (humanized IgG1 mAb) targets CD123 (IL-3RA) – highly expressed on malignant hematopoietic cells (e.g., AML, BPDCN) and critical for IL-3-mediated cell survival/proliferation – blocking related signaling in myeloid malignancies. Unlike therapeutic pivekimab sunirine (with cytotoxic payload), this unconjugated biosimilar is research-only, suited for studying IL-3 signaling, CD123 expression and receptor blockade in hematologic cancers.
| Product Name | BioSIM anti-Human IL-3Ra/CD123 Antibody (Pivekimab Biosimilar), Research Grade |
| Size | 1mg/5mg |
| Isotype | IgG1-kappa |
| Target | IL-3Ra/CD123 |
| Other Names | G4723ACAS: 2234335-84-1 |
| CAS | 2234335-84-1 |
| Reactivity | Human |
| Host Species | Humanized |
| Background | This biosimilar antibody shares the same variable regions as therapeutic Pivekimab, ideal for research. Pivekimab (humanized IgG1 mAb) targets CD123 (IL-3RA) – highly expressed on malignant hematopoietic cells (e.g., AML, BPDCN) and critical for IL-3-mediated cell survival/proliferation – blocking related signaling in myeloid malignancies. Unlike therapeutic pivekimab sunirine (with cytotoxic payload), this unconjugated biosimilar is research-only, suited for studying IL-3 signaling, CD123 expression and receptor blockade in hematologic cancers. |
| Applications | ELISA, FACS, Functional assay, Research in vivo |
| Purification | Protein A/G |
| Storage | To ensure appropriate storage, Please avoid repeated freeze thaw cycles. Keep the product at 4°C for short-term needs (1–2 weeks); Store at -20°C for up to 12 months. For long-term storage, store at -80°C. |
| Shipping | 2-8°C with blue ice |
| Concentration | Lot specific, generally ≥ 5.0 mg/ml |
| Shelf Life | 12 months from the date of receipt if stored as recommended |
| Formulation | PBS, pH 7.4, contains no stabilizers or preservatives |
| Sterility | 0.2 μM filtered |
| Endotoxin | ≤ 1.0 EU/mg |
| Purity | 99% |
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