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This biosimilar, sharing therapeutic Tremelimumab’s variable regions, is a fully human monoclonal antibody binding human CTLA-4 (CD152)—a 33 kDa CD28-family receptor on activated T/B cells that negatively regulates immunity. It blocks CTLA-4’s inhibitory signal (aiding T cells to kill cancer cells, for checkpoint blockade) and is a non-complement-fixing IgG2, unlike CTLA-4-targeting Ipilimumab (IgG1).
| Product Name | BioSIM anti-Human CTLA-4/CD152 Antibody (Tremelimumab Biosimilar), Research Grade |
| Size | 1mg/5mg |
| Isotype | IgG2-kappa |
| Target | CTLA-4/CD152 |
| Other Names | Ticilimumab, CP-675, CP-675, 206, CP-675206clone11.2.1, CAS: 745013-59-6 |
| CAS | 745013-59-6 |
| Reactivity | Human |
| Host Species | Human |
| Background | This biosimilar, sharing therapeutic Tremelimumab’s variable regions, is a fully human monoclonal antibody binding human CTLA-4 (CD152)—a 33 kDa CD28-family receptor on activated T/B cells that negatively regulates immunity. It blocks CTLA-4’s inhibitory signal (aiding T cells to kill cancer cells, for checkpoint blockade) and is a non-complement-fixing IgG2, unlike CTLA-4-targeting Ipilimumab (IgG1). |
| Applications | ELISA, FACS, Functional assay, Research in vivo |
| Purification | Protein A/G |
| Storage | To ensure appropriate storage, Please avoid repeated freeze thaw cycles. Keep the product at 4°C for short-term needs (1–2 weeks); Store at -20°C for up to 12 months. For long-term storage, store at -80°C. |
| Shipping | 2-8°C with blue ice |
| Concentration | Lot specific, generally ≥ 5.0 mg/ml |
| Shelf Life | 12 months from the date of receipt if stored as recommended |
| Formulation | PBS, pH 7.4, contains no stabilizers or preservatives |
| Sterility | 0.2 μM filtered |
| Endotoxin | ≤ 1.0 EU/mg |
| Purity | 99% |
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