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This non-therapeutic biosimilar has Relatlimab’s variable regions, ideal for research. It binds human LAG-3 (CD223: 70 kDa transmembrane glycoprotein, Lag3-encoded, immunoglobulin superfamily, expressed on activated T/NK/regulatory T cells). LAG-3 binds MHC II (higher affinity than CD4), acts like CTLA-4/PD-1 (downregulates TCR signaling), aids regulatory T cell suppression, and activates antigen-presenting cells. Relatlimab (LAG-3 inhibitor) + lenalidomide boosts T-cell IL-2 and NK-cell antibody-dependent cytotoxicity.
| Product Name | BioSIM anti-Human LAG3/CD223 Antibody (Relatlimab Biosimilar), Research Grade |
| Size | 1mg/5mg |
| Isotype | IgG4-kappa |
| Target | LAG3/CD223 |
| Other Names | BMS-986016, ONO-4482, CAS: 1673516-98-7 |
| CAS | 1673516-98-7 |
| Reactivity | Human |
| Host Species | Human |
| Background | This non-therapeutic biosimilar has Relatlimab’s variable regions, ideal for research. It binds human LAG-3 (CD223: 70 kDa transmembrane glycoprotein, Lag3-encoded, immunoglobulin superfamily, expressed on activated T/NK/regulatory T cells). LAG-3 binds MHC II (higher affinity than CD4), acts like CTLA-4/PD-1 (downregulates TCR signaling), aids regulatory T cell suppression, and activates antigen-presenting cells. Relatlimab (LAG-3 inhibitor) + lenalidomide boosts T-cell IL-2 and NK-cell antibody-dependent cytotoxicity. |
| Applications | ELISA, FACS, Functional assay, Research in vivo |
| Purification | Protein A/G |
| Storage | To ensure appropriate storage, Please avoid repeated freeze thaw cycles. Keep the product at 4°C for short-term needs (1–2 weeks); Store at -20°C for up to 12 months. For long-term storage, store at -80°C. |
| Shipping | 2-8°C with blue ice |
| Concentration | Lot specific, generally ≥ 5.0 mg/ml |
| Shelf Life | 12 months from the date of receipt if stored as recommended |
| Formulation | PBS, pH 7.4, contains no stabilizers or preservatives |
| Sterility | 0.2 μM filtered |
| Endotoxin | ≤ 1.0 EU/mg |
| Purity | 99% |
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