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BiosimilarsInvestigate biological therapeutic mechanisms with cost-effective, research-grade biosimilar antibodies.
This non-therapeutic biosimilar shares variable regions with therapeutic Tisotumab, ideal for research. Tisotumab (humanized IgG1 mAb) binds human/monkey tissue factor (TF/CD142/F3). TF, a transmembrane glycoprotein, initiates coagulation via complexing with factor VII, and involves in tumor-related signaling (e.g., MAPK, PI3K-AKT, Wnt). Aberrantly expressed in some tumors, TF is targeted by MMAE-based ADC (tisotumab vedotin) for anti-cancer effects—this biosimilar is the ADC’s antibody part.
| Product Name | BioSIM anti-Human Tissue factor/CD142 Antibody (Tisotumab Biosimilar), Research Grade |
| Size | 1mg/5mg |
| Isotype | IgG1-kappa |
| Target | Tissue factor/CD142 |
| Other Names | HuMax-TF-ADC, TF-011-MMAE, HuMax-TF, CAS: 1418628-81-5 |
| CAS | 1418628-81-5 |
| Reactivity | Human |
| Host Species | Human |
| Background | This non-therapeutic biosimilar shares variable regions with therapeutic Tisotumab, ideal for research. Tisotumab (humanized IgG1 mAb) binds human/monkey tissue factor (TF/CD142/F3). TF, a transmembrane glycoprotein, initiates coagulation via complexing with factor VII, and involves in tumor-related signaling (e.g., MAPK, PI3K-AKT, Wnt). Aberrantly expressed in some tumors, TF is targeted by MMAE-based ADC (tisotumab vedotin) for anti-cancer effects—this biosimilar is the ADC’s antibody part. |
| Applications | ELISA, FACS, Functional assay, Research in vivo |
| Purification | Protein A/G |
| Storage | To ensure appropriate storage, Please avoid repeated freeze thaw cycles. Keep the product at 4°C for short-term needs (1–2 weeks); Store at -20°C for up to 12 months. For long-term storage, store at -80°C. |
| Shipping | 2-8°C with blue ice |
| Concentration | Lot specific, generally ≥ 5.0 mg/ml |
| Shelf Life | 12 months from the date of receipt if stored as recommended |
| Formulation | PBS, pH 7.4, contains no stabilizers or preservatives |
| Sterility | 0.2 μM filtered |
| Endotoxin | ≤ 1.0 EU/mg |
| Purity | 99% |
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