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This non-therapeutic biosimilar shares variable regions with therapeutic Belantamab (humanized IgG1 mAb targeting BCMA/CD269/TNFRSF17), ideal for research. BCMA (type III membrane glycoprotein) is on mature plasma B-cells (normal lymphoid tissues) and highly in multiple myeloma, binds APRIL (higher affinity than BAFF), promotes B-cell survival, regulates humoral immunity, involves NF-κB/JNK-3 pathways. Belantamab-mafodotin ADC induces ADCC and cancer cell apoptosis.
| Product Name | BioSIM anti-Human TNFRSF17/CD269 Antibody (Belantamab Biosimilar), Research Grade |
| Size | 1mg/5mg |
| Isotype | IgG1-kappa |
| Target | TNFRSF17/CD269 |
| Other Names | BCMA, 2857916, GSK2857916, J6M0, J6M0-mcMMAF, CAS: 2061894-48-0 |
| CAS | 2061894-48-0 |
| Reactivity | Human |
| Host Species | Humanized |
| Background | This non-therapeutic biosimilar shares variable regions with therapeutic Belantamab (humanized IgG1 mAb targeting BCMA/CD269/TNFRSF17), ideal for research. BCMA (type III membrane glycoprotein) is on mature plasma B-cells (normal lymphoid tissues) and highly in multiple myeloma, binds APRIL (higher affinity than BAFF), promotes B-cell survival, regulates humoral immunity, involves NF-κB/JNK-3 pathways. Belantamab-mafodotin ADC induces ADCC and cancer cell apoptosis. |
| Applications | ELISA, FACS, Functional assay, Research in vivo |
| Purification | Protein A/G |
| Storage | To ensure appropriate storage, Please avoid repeated freeze thaw cycles. Keep the product at 4°C for short-term needs (1–2 weeks); Store at -20°C for up to 12 months. For long-term storage, store at -80°C. |
| Shipping | 2-8°C with blue ice |
| Concentration | Lot specific, generally ≥ 5.0 mg/ml |
| Shelf Life | 12 months from the date of receipt if stored as recommended |
| Formulation | PBS, pH 7.4, contains no stabilizers or preservatives |
| Sterility | 0.2 μM filtered |
| Endotoxin | ≤ 1.0 EU/mg |
| Purity | 99% |
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