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This non-therapeutic biosimilar antibody has the same variable regions as Zolbetuximab, ideal for research. It reacts with human Claudin 18.2 (a claudin family member, common in gastric/pancreatic cancers, only present in healthy gastric mucosa). Claudins impact tight junctions, tumorigenesis; their altered expression promotes epithelial cancers. Zolbetuximab showed antitumor activity via ADCC/CDC in humanized prostate cancer mouse models.
| Product Name | BioSIM anti-Human Claudin18.2/CLDN18.2 Antibody (Zolbetuximab Biosimilar), Research Grade |
| Size | 1mg/5mg |
| Isotype | IgG1-kappa |
| Target | Claudin18.2/CLDN18.2 |
| Other Names | Claudin18.2, GC-182, IMAB-362, IMAB362, Claudiximab, CAS: 1496553-00-4 |
| CAS | 1496553-00-4 |
| Reactivity | Human |
| Host Species | Chimeric |
| Background | This non-therapeutic biosimilar antibody has the same variable regions as Zolbetuximab, ideal for research. It reacts with human Claudin 18.2 (a claudin family member, common in gastric/pancreatic cancers, only present in healthy gastric mucosa). Claudins impact tight junctions, tumorigenesis; their altered expression promotes epithelial cancers. Zolbetuximab showed antitumor activity via ADCC/CDC in humanized prostate cancer mouse models. |
| Applications | ELISA, FACS, Functional assay, Research in vivo |
| Purification | Protein A/G |
| Storage | To ensure appropriate storage, Please avoid repeated freeze thaw cycles. Keep the product at 4°C for short-term needs (1–2 weeks); Store at -20°C for up to 12 months. For long-term storage, store at -80°C. |
| Shipping | 2-8°C with blue ice |
| Concentration | Lot specific, generally ≥ 5.0 mg/ml |
| Shelf Life | 12 months from the date of receipt if stored as recommended |
| Formulation | PBS, pH 7.4, contains no stabilizers or preservatives |
| Sterility | 0.2 μM filtered |
| Endotoxin | ≤ 1.0 EU/mg |
| Purity | 99% |
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