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This non-therapeutic biosimilar antibody shares the same variable regions as therapeutic Tinurilimab (a humanized IgG2 mAb targeting CEACAM6, a carcinoembryonic antigen-related adhesion molecule), ideal for research. CEACAM6 is overexpressed in epithelial cancers (e.g., NSCLC, pancreatic), linked to tumor progression, acts as an immune checkpoint (suppressing T-cells), and promotes EMT/invasion. The biosimilar suits CEACAM6-mediated signaling, tumor immunology, and targeted therapy studies.
| Product Name | BioSIM anti-Human CEACAM6/CD66c Antibody (Tinurilimab Biosimilar), Research Grade |
| Size | 1mg/5mg |
| Isotype | IgG1-kappa |
| Target | CEACAM6/CD66c |
| Other Names | BAY-1834942, CAS: 2226224-30-0 |
| CAS | 2226224-30-0 |
| Reactivity | Human |
| Host Species | Humanized |
| Background | This non-therapeutic biosimilar antibody shares the same variable regions as therapeutic Tinurilimab (a humanized IgG2 mAb targeting CEACAM6, a carcinoembryonic antigen-related adhesion molecule), ideal for research. CEACAM6 is overexpressed in epithelial cancers (e.g., NSCLC, pancreatic), linked to tumor progression, acts as an immune checkpoint (suppressing T-cells), and promotes EMT/invasion. The biosimilar suits CEACAM6-mediated signaling, tumor immunology, and targeted therapy studies. |
| Applications | ELISA, FACS, Functional assay, Research in vivo |
| Purification | Protein A/G |
| Storage | To ensure appropriate storage, Please avoid repeated freeze thaw cycles. Keep the product at 4°C for short-term needs (1–2 weeks); Store at -20°C for up to 12 months. For long-term storage, store at -80°C. |
| Shipping | 2-8°C with blue ice |
| Concentration | Lot specific, generally ≥ 5.0 mg/ml |
| Shelf Life | 12 months from the date of receipt if stored as recommended |
| Formulation | PBS, pH 7.4, contains no stabilizers or preservatives |
| Sterility | 0.2 μM filtered |
| Endotoxin | ≤ 1.0 EU/mg |
| Purity | 99% |
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