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This non-therapeutic Ramucirumab biosimilar (ideal for research, same variable regions as therapeutic Ramucirumab) reacts with human VEGFR-2 (CD309/KDR/Flk-1, tyrosine protein kinase family). VEGFR-2 binds VEGF to regulate vascular development/permeability, highly expressed on endothelial cells in adult heart/lung/kidney/brain/skeletal muscle. It binds VEGFR-2’s extracellular domain, blocks VEGF-A/C/D, inhibiting VEGF-mediated tumor angiogenesis.
| Product Name | BioSIM anti-Human VEGFR2 Antibody (Ramucirumab Biosimilar), Research Grade |
| Size | 1mg/5mg |
| Isotype | IgG1-kappa |
| Target | VEGFR2 |
| Other Names | 1121B, IMC-1121B, LY3009806, CAS: 947687-13-0 |
| CAS | 947687-13-0 |
| Reactivity | Human |
| Host Species | Human |
| Background | This non-therapeutic Ramucirumab biosimilar (ideal for research, same variable regions as therapeutic Ramucirumab) reacts with human VEGFR-2 (CD309/KDR/Flk-1, tyrosine protein kinase family). VEGFR-2 binds VEGF to regulate vascular development/permeability, highly expressed on endothelial cells in adult heart/lung/kidney/brain/skeletal muscle. It binds VEGFR-2’s extracellular domain, blocks VEGF-A/C/D, inhibiting VEGF-mediated tumor angiogenesis. |
| Applications | ELISA, FACS, Functional assay, Research in vivo |
| Purification | Protein A/G |
| Storage | To ensure appropriate storage, Please avoid repeated freeze thaw cycles. Keep the product at 4°C for short-term needs (1–2 weeks); Store at -20°C for up to 12 months. For long-term storage, store at -80°C. |
| Shipping | 2-8°C with blue ice |
| Concentration | Lot specific, generally ≥ 5.0 mg/ml |
| Shelf Life | 12 months from the date of receipt if stored as recommended |
| Formulation | PBS, pH 7.4, contains no stabilizers or preservatives |
| Sterility | 0.2 μM filtered |
| Endotoxin | ≤ 1.0 EU/mg |
| Purity | 99% |
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