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BiosimilarsInvestigate biological therapeutic mechanisms with cost-effective, research-grade biosimilar antibodies.
This non-therapeutic biosimilar uses Avelumab’s variable regions, ideal for research. It reacts with human PD-L1 (B7-H1/CD274, a 40 kDa type I transmembrane protein in B7/Ig superfamily) expressed on various cells. PD-L1 binding to PD-1 inhibits TCR-mediated T cell proliferation/cytokine production, aiding tumor immune evasion. Avelumab blocks PD-L1’s interaction with PD-1 and CD80.
| Product Name | BioSIM anti-Human PD-L1/CD274 Antibody (Avelumab Biosimilar), Research Grade |
| Size | 1mg/5mg |
| Isotype | IgG1-lambda |
| Target | PD-L1/CD274 |
| Other Names | MSB-0010718C, MSB0010682, CAS: 1537032-82-8 |
| CAS | 1537032-82-8 |
| Reactivity | Human |
| Host Species | Human |
| Background | This non-therapeutic biosimilar uses Avelumab’s variable regions, ideal for research. It reacts with human PD-L1 (B7-H1/CD274, a 40 kDa type I transmembrane protein in B7/Ig superfamily) expressed on various cells. PD-L1 binding to PD-1 inhibits TCR-mediated T cell proliferation/cytokine production, aiding tumor immune evasion. Avelumab blocks PD-L1’s interaction with PD-1 and CD80. |
| Applications | ELISA, FACS, Functional assay, Research in vivo |
| Purification | Protein A/G |
| Storage | To ensure appropriate storage, Please avoid repeated freeze thaw cycles. Keep the product at 4°C for short-term needs (1–2 weeks); Store at -20°C for up to 12 months. For long-term storage, store at -80°C. |
| Shipping | 2-8°C with blue ice |
| Concentration | Lot specific, generally ≥ 5.0 mg/ml |
| Shelf Life | 12 months from the date of receipt if stored as recommended |
| Formulation | PBS, pH 7.4, contains no stabilizers or preservatives |
| Sterility | 0.2 μM filtered |
| Endotoxin | ≤ 1.0 EU/mg |
| Purity | 99% |
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