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This non-therapeutic biosimilar has the same variable regions as Elotuzumab (a humanized mAb targeting CD319/SLAMF7, expressed on myeloma and normal immune cells). It activates NK cells (via SLAMF7/Fc receptors), boosts CD69/IFN-γ/granzyme B, promotes myeloma cell death (ADCC), disrupts drug resistance, reduces SLAMF7+ myeloma xenografts, and enhances anti-tumor activity with lenalidomide.
| Product Name | BioSIM anti-Human SLAMF7 Antibody (Elotuzumab Biosimilar), Research Grade |
| Size | 1mg/5mg |
| Isotype | IgG1-kappa |
| Target | SLAMF7 |
| Other Names | BMS-901608, PDL063, HuLuc63, CAS: 915296-00-3 |
| CAS | 915296-00-3 |
| Reactivity | Human |
| Host Species | Humanized |
| Background | This non-therapeutic biosimilar has the same variable regions as Elotuzumab (a humanized mAb targeting CD319/SLAMF7, expressed on myeloma and normal immune cells). It activates NK cells (via SLAMF7/Fc receptors), boosts CD69/IFN-γ/granzyme B, promotes myeloma cell death (ADCC), disrupts drug resistance, reduces SLAMF7+ myeloma xenografts, and enhances anti-tumor activity with lenalidomide. |
| Applications | ELISA, FACS, Functional assay, Research in vivo |
| Purification | Protein A/G |
| Storage | To ensure appropriate storage, Please avoid repeated freeze thaw cycles. Keep the product at 4°C for short-term needs (1–2 weeks); Store at -20°C for up to 12 months. For long-term storage, store at -80°C. |
| Shipping | 2-8°C with blue ice |
| Concentration | Lot specific, generally ≥ 5.0 mg/ml |
| Shelf Life | 12 months from the date of receipt if stored as recommended |
| Formulation | PBS, pH 7.4, contains no stabilizers or preservatives |
| Sterility | 0.2 μM filtered |
| Endotoxin | ≤ 1.0 EU/mg |
| Purity | 99% |
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