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This non-therapeutic biosimilar antibody, sharing variable regions with therapeutic Belimumab, suits research. Belimumab is a humanized IgG1λ monoclonal antibody targeting BAFF (BLyS/TNFSF13B), a TNF-family cytokine from monocytes/macrophages/dendritic/lymphoid cells (B/activated T cells), existing as transmembrane/soluble forms, binding BCMA/TACI/BAFF-R. BAFF boosts B/T cell function, B cell survival/differentiation into plasma cells, and is elevated in SLE. Belimumab inhibits B cell survival by blocking BAFF-receptor interaction, underpinning SLE immunotherapy.
| Product Name | BioSIM anti-Human BAFF/CD257 Antibody (Belimumab Biosimilar), Research Grade |
| Size | 1mg/5mg |
| Isotype | IgG1-lambda |
| Target | BAFF/CD257 |
| Other Names | LymphoStat-B, hBlySmAb-1.1, CAS: 356547-88-1 |
| CAS | 356547-88-1 |
| Reactivity | Human |
| Host Species | Human |
| Background | This non-therapeutic biosimilar antibody, sharing variable regions with therapeutic Belimumab, suits research. Belimumab is a humanized IgG1λ monoclonal antibody targeting BAFF (BLyS/TNFSF13B), a TNF-family cytokine from monocytes/macrophages/dendritic/lymphoid cells (B/activated T cells), existing as transmembrane/soluble forms, binding BCMA/TACI/BAFF-R. BAFF boosts B/T cell function, B cell survival/differentiation into plasma cells, and is elevated in SLE. Belimumab inhibits B cell survival by blocking BAFF-receptor interaction, underpinning SLE immunotherapy. |
| Applications | ELISA, FACS, Functional assay, Research in vivo |
| Purification | Protein A/G |
| Storage | To ensure appropriate storage, Please avoid repeated freeze thaw cycles. Keep the product at 4°C for short-term needs (1–2 weeks); Store at -20°C for up to 12 months. For long-term storage, store at -80°C. |
| Shipping | 2-8°C with blue ice |
| Concentration | Lot specific, generally ≥ 5.0 mg/ml |
| Shelf Life | 12 months from the date of receipt if stored as recommended |
| Formulation | PBS, pH 7.4, contains no stabilizers or preservatives |
| Sterility | 0.2 μM filtered |
| Endotoxin | ≤ 1.0 EU/mg |
| Purity | 99% |
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