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This biosimilar antibody has the same variable regions as therapeutic antibody Sabatolimab, ideal for research. Sabatolimab, a humanized IgG4 monoclonal antibody, targets human TIM-3 (CD366) — a 60 kDa TIM-family immune checkpoint receptor. It binds TIM-3 with subnanomolar affinity, blocks its ligand interaction (e.g., with phosphatidylserine), and TIM-3 is explored in cancer immunotherapy.
| Product Name | BioSIM anti-Human TIM-3/CD366 Antibody (Sabatolimab Biosimilar), Research Grade |
| Size | 1mg/5mg |
| Isotype | IgG4-kappa |
| Target | TIM-3/CD366 |
| Other Names | MBG-453, CAS: 2252262-24-9 |
| CAS | 2252262-24-9 |
| Reactivity | Human |
| Host Species | Humanized |
| Background | This biosimilar antibody has the same variable regions as therapeutic antibody Sabatolimab, ideal for research. Sabatolimab, a humanized IgG4 monoclonal antibody, targets human TIM-3 (CD366) — a 60 kDa TIM-family immune checkpoint receptor. It binds TIM-3 with subnanomolar affinity, blocks its ligand interaction (e.g., with phosphatidylserine), and TIM-3 is explored in cancer immunotherapy. |
| Applications | ELISA, FACS, Functional assay, Research in vivo |
| Purification | Protein A/G |
| Storage | To ensure appropriate storage, Please avoid repeated freeze thaw cycles. Keep the product at 4°C for short-term needs (1–2 weeks); Store at -20°C for up to 12 months. For long-term storage, store at -80°C. |
| Shipping | 2-8°C with blue ice |
| Concentration | Lot specific, generally ≥ 5.0 mg/ml |
| Shelf Life | 12 months from the date of receipt if stored as recommended |
| Formulation | PBS, pH 7.4, contains no stabilizers or preservatives |
| Sterility | 0.2 μM filtered |
| Endotoxin | ≤ 1.0 EU/mg |
| Purity | 99% |
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