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BiosimilarsInvestigate biological therapeutic mechanisms with cost-effective, research-grade biosimilar antibodies.
This non-therapeutic Nivolumab biosimilar (same variable regions, ideal for research) binds human PD-1 (CD279; 50-55 kDa, Pdcd1-encoded, CD28 family, expressed on immune cells). PD-1 has an ITIM, negatively regulates TCR signals via PD-L1/PD-L2, inhibiting T-cell activation. Tumors overexpress PD-L1 (resisting CD8 T-cell lysis); anti-PD-1 treats cancer. Nivolumab blocks PD-1-ligand interaction.
| Product Name | BioSIM anti-Human PD-1/CD279 Antibody (Nivolumab Biosimilar), Research Grade |
| Size | 1mg/5mg |
| Isotype | IgG4-kappa |
| Target | PD-1/CD279 |
| Other Names | BMS-936558, MDX-1106, ONO-4538, CAS: 946414-94-4 |
| CAS | 946414-94-4 |
| Reactivity | Human |
| Host Species | Human |
| Background | This non-therapeutic Nivolumab biosimilar (same variable regions, ideal for research) binds human PD-1 (CD279; 50-55 kDa, Pdcd1-encoded, CD28 family, expressed on immune cells). PD-1 has an ITIM, negatively regulates TCR signals via PD-L1/PD-L2, inhibiting T-cell activation. Tumors overexpress PD-L1 (resisting CD8 T-cell lysis); anti-PD-1 treats cancer. Nivolumab blocks PD-1-ligand interaction. |
| Applications | ELISA, FACS, Functional assay, Research in vivo |
| Purification | Protein A/G |
| Storage | To ensure appropriate storage, Please avoid repeated freeze thaw cycles. Keep the product at 4°C for short-term needs (1–2 weeks); Store at -20°C for up to 12 months. For long-term storage, store at -80°C. |
| Shipping | 2-8°C with blue ice |
| Concentration | Lot specific, generally ≥ 5.0 mg/ml |
| Shelf Life | 12 months from the date of receipt if stored as recommended |
| Formulation | PBS, pH 7.4, contains no stabilizers or preservatives |
| Sterility | 0.2 μM filtered |
| Endotoxin | ≤ 1.0 EU/mg |
| Purity | 99% |
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