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This non-therapeutic Pembrolizumab biosimilar, ideal for research, shares the therapeutic antibody’s variable regions and binds human PD-1 (CD279). PD-1 (50-55 kDa, Pdcd1-encoded, CD28 family) is transiently expressed on immune cells, has an ITIM, binds PD-L1/2 to inhibit T cells, and supports peripheral tolerance. Tumor PD-L1 overexpression resists CD8 T-cell lysis; anti-PD-1 aids cancer treatment. This biosimilar blocks PD-1-ligand interaction.
| Product Name | BioSIM anti-Human PD-1/CD279 Antibody (Pembrolizumab Biosimilar), Research Grade |
| Size | 1mg/5mg |
| Isotype | IgG4-kappa |
| Target | PD-1/CD279 |
| Other Names | MK-3475, CAS: 1374853-91-4 |
| CAS | 1374853-91-4 |
| Reactivity | Human |
| Host Species | Humanized |
| Background | This non-therapeutic Pembrolizumab biosimilar, ideal for research, shares the therapeutic antibody’s variable regions and binds human PD-1 (CD279). PD-1 (50-55 kDa, Pdcd1-encoded, CD28 family) is transiently expressed on immune cells, has an ITIM, binds PD-L1/2 to inhibit T cells, and supports peripheral tolerance. Tumor PD-L1 overexpression resists CD8 T-cell lysis; anti-PD-1 aids cancer treatment. This biosimilar blocks PD-1-ligand interaction. |
| Applications | ELISA, FACS, Functional assay, Research in vivo |
| Purification | Protein A/G |
| Storage | To ensure appropriate storage, Please avoid repeated freeze thaw cycles. Keep the product at 4°C for short-term needs (1–2 weeks); Store at -20°C for up to 12 months. For long-term storage, store at -80°C. |
| Shipping | 2-8°C with blue ice |
| Concentration | Lot specific, generally ≥ 5.0 mg/ml |
| Shelf Life | 12 months from the date of receipt if stored as recommended |
| Formulation | PBS, pH 7.4, contains no stabilizers or preservatives |
| Sterility | 0.2 μM filtered |
| Endotoxin | ≤ 1.0 EU/mg |
| Purity | 99% |
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