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This non-therapeutic biosimilar (same variable regions as Tiragolumab, ideal for research) binds human TIGIT (26 kDa PVR-family transmembrane protein, expressed on mouse follicular T helper cells & human T cell subsets/NK cells, negatively regulating NK/T activation). It blocks TIGIT-CD112/CD155 interaction, enhances CD226 signaling, activates anti-cancer T-cell immunity, and treats solid malignancies (e.g., NSCLC) alone or with PD-L1 inhibitors.
| Product Name | BioSIM anti-Human TIGIT Antibody (Tiragolumab Biosimilar), Research Grade |
| Size | 1mg/5mg |
| Isotype | IgG1-kappa |
| Target | TIGIT |
| Other Names | MTIG-7192-A, MTIG-7192A, MTIG7192A, RG-6058, RO-7092284, RO7092284, CAS: 1918185-84-8 |
| CAS | 1918185-84-8 |
| Reactivity | Human |
| Host Species | Human |
| Background | This non-therapeutic biosimilar (same variable regions as Tiragolumab, ideal for research) binds human TIGIT (26 kDa PVR-family transmembrane protein, expressed on mouse follicular T helper cells & human T cell subsets/NK cells, negatively regulating NK/T activation). It blocks TIGIT-CD112/CD155 interaction, enhances CD226 signaling, activates anti-cancer T-cell immunity, and treats solid malignancies (e.g., NSCLC) alone or with PD-L1 inhibitors. |
| Applications | ELISA, FACS, Functional assay, Research in vivo |
| Purification | Protein A/G |
| Storage | To ensure appropriate storage, Please avoid repeated freeze thaw cycles. Keep the product at 4°C for short-term needs (1–2 weeks); Store at -20°C for up to 12 months. For long-term storage, store at -80°C. |
| Shipping | 2-8°C with blue ice |
| Concentration | Lot specific, generally ≥ 5.0 mg/ml |
| Shelf Life | 12 months from the date of receipt if stored as recommended |
| Formulation | PBS, pH 7.4, contains no stabilizers or preservatives |
| Sterility | 0.2 μM filtered |
| Endotoxin | ≤ 1.0 EU/mg |
| Purity | 99% |
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