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BiosimilarsInvestigate biological therapeutic mechanisms with cost-effective, research-grade biosimilar antibodies.
This non-therapeutic biosimilar shares Urelumab’s variable regions, ideal for research. It targets 4-1BB (CD137, TNF superfamily, expressed in lymphoid tissues/activated immune cells, not resting T/B cells). As a humanized IgG4 with S228P mutation (boosts stability), it’s agonistic—mimics ligand cross-linking, triggers T-cell costimulation, enhances NK cell ADCC, and boosts T cell-mediated antitumor immunity.
| Product Name | BioSIM anti-Human 4-1BB/CD137 Antibody (Urelumab Biosimilar), Research Grade |
| Size | 1mg/5mg |
| Isotype | IgG4-kappa |
| Target | 4-1BB/CD137 |
| Other Names | BMS-663513, CAS: 934823-49-1 |
| CAS | 934823-49-1 |
| Reactivity | Human |
| Host Species | Human |
| Background | This non-therapeutic biosimilar shares Urelumab’s variable regions, ideal for research. It targets 4-1BB (CD137, TNF superfamily, expressed in lymphoid tissues/activated immune cells, not resting T/B cells). As a humanized IgG4 with S228P mutation (boosts stability), it’s agonistic—mimics ligand cross-linking, triggers T-cell costimulation, enhances NK cell ADCC, and boosts T cell-mediated antitumor immunity. |
| Applications | ELISA, FACS, Functional assay, Research in vivo |
| Purification | Protein A/G |
| Storage | To ensure appropriate storage, Please avoid repeated freeze thaw cycles. Keep the product at 4°C for short-term needs (1–2 weeks); Store at -20°C for up to 12 months. For long-term storage, store at -80°C. |
| Shipping | 2-8°C with blue ice |
| Concentration | Lot specific, generally ≥ 5.0 mg/ml |
| Shelf Life | 12 months from the date of receipt if stored as recommended |
| Formulation |
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| Sterility | 0.2 μM filtered |
| Endotoxin | ≤ 1.0 EU/mg |
| Purity | 99% |
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