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BiosimilarsInvestigate biological therapeutic mechanisms with cost-effective, research-grade biosimilar antibodies.
This non-therapeutic biosimilar shares the same variable regions as therapeutic Bevacizumab, ideal for research. It reacts with human VEGF (a 45 kDa homodimeric, disulfide-linked glycoprotein) that aids angiogenesis, vasculogenesis, endothelial growth, and promotes mitogenesis, chemotaxis, vascular permeability. Tumors rely on angiogenesis; inhibiting VEGF-receptor binding is key for tumor therapy. Bevacizumab neutralizes VEGF by blocking this interaction, inhibiting tumor growth.
| Product Name | BioSIM anti-Human VEGFA Antibody (Bevacizumab Biosimilar), Research Grade |
| Size | 1mg/5mg |
| Isotype | IgG1-kappa |
| Target | VEGFA |
| Other Names | 12-IgG1, F(ab)-12IgG1, Fab-12IgG1, rhuMAb-VEGF, ABP215, CAS: 216974-75-3 |
| CAS | 216974-75-3 |
| Reactivity | Human |
| Host Species | Humanized |
| Background | This non-therapeutic biosimilar shares the same variable regions as therapeutic Bevacizumab, ideal for research. It reacts with human VEGF (a 45 kDa homodimeric, disulfide-linked glycoprotein) that aids angiogenesis, vasculogenesis, endothelial growth, and promotes mitogenesis, chemotaxis, vascular permeability. Tumors rely on angiogenesis; inhibiting VEGF-receptor binding is key for tumor therapy. Bevacizumab neutralizes VEGF by blocking this interaction, inhibiting tumor growth. |
| Applications | ELISA, FACS, Functional assay, Research in vivo |
| Purification | Protein A/G |
| Storage | To ensure appropriate storage, Please avoid repeated freeze thaw cycles. Keep the product at 4°C for short-term needs (1–2 weeks); Store at -20°C for up to 12 months. For long-term storage, store at -80°C. |
| Shipping | 2-8°C with blue ice |
| Concentration | Lot specific, generally ≥ 5.0 mg/ml |
| Shelf Life | 12 months from the date of receipt if stored as recommended |
| Formulation | PBS, pH 7.4, contains no stabilizers or preservatives |
| Sterility | 0.2 μM filtered |
| Endotoxin | ≤ 1.0 EU/mg |
| Purity | 99% |
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