In immunology and the field of cell and gene therapy (CGT), selective elimination of defined cell populations—commonly referred to as cell depletion—is a widely adopted strategy to interrogate the functional roles of specific cellular subsets and their associated molecular targets.
InvivoCrown offers a range of monoclonal antibodies to mouse cell surface proteins for in vivo cell-specific depletion studies. These antibodies are validated for in vivo use, where systemic administration enables the targeted depletion of specific cell populations. Mechanistically, these depletion antibodies act through multiple effector pathways, including antibody-dependent cellular cytotoxicity (ADCC), complement-dependent cytotoxicity (CDC), and antibody-dependent cellular phagocytosis (ADCP).
Our Most Popular Cell Depletion Antibodies:
|
Cell Type |
Item Number |
Name |
|
T cells |
IV0121 |
InVivoPro Anti-Mouse CD3ε in vivo antibody, Clone 145-2C11 |
|
CD4+T cells |
IV0102 |
InVivoPro Anti-Mouse CD4 in vivo antibody, Clone GK1.5 |
|
CD8+T cells |
IV0104 |
InVivoPro Anti-Mouse CD8α in vivo antibody, Clone 2.43 |
|
IV0119 |
InVivoPro Anti-Mouse CD8α in vivo antibody, Clone 53-6.7 |
|
|
IV0117 |
InVivoPro Anti-Mouse CD8β (Lyt 3.2) in vivo antibody, Clone 53-5.8 |
|
|
NKcells |
IV0111 |
InVivoPro Anti-Mouse NK1.1(CD161) Antibody in vivo antibody, Clone PK136 |
|
Neutrophils |
IV0113 |
InVivoPro Anti-Mouse Ly6G/Ly6C (Gr-1) in vivo antibody, Clone RB6-8C5 |
|
IV0103 |
InVivoPro Anti-Mouse Ly6G in vivo antibody, Clone 1A8 |
|
|
Macrophages |
IV0114 |
InVivoPro Anti-Mouse CSF1R (CD115) in vivo antibody, Clone AFS98 |
|
Monocytes |
IV0113 |
InVivoPro Anti-Mouse Ly6G/Ly6C (Gr-1) in vivo antibody, Clone RB6-8C5 |
|
IV0114 |
InVivoPro Anti-Mouse CSF1R (CD115) in vivo antibody, Clone AFS98 |
|
|
B cells |
IV0135 |
InVivoPro Anti-Mouse CD20 in vivo antibody, Clone MB20-11 |
